The explosion occurred at 10 a.m. on the main Tahrir Square, a commercial area that has been targeted by bombers several times in the past few months.
Police Lt.Ahmed Ali said the blast killed two civilians and wounding 18 others.
A building exploded on the square on May 25, killing three people and wounding 11, and police said they suspected a bomb-making factory had blown up, the AP reports.
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