A roadside bomb killed three American soldiers and wounded two in Baghdad.
A U.S. statement said the bomb was an explosively-formed penetrator, a type which the U.S. says Iran has been supplying to Shiite militias, a charge the Iranians deny.
The U.S. said the blast occurred Tuesday in east Baghdad but gave no further details.
However, a U.S. Humvee was seen burning Tuesday at an intersection in Mashtal section of eastern Baghdad.
Last week, anti-American cleric Muqtada al-Sadr ordered a six-month suspension of operations by his Mahdi Army militia.
U.S. officials believe mainstream Mahdi forces have generally stuck by the order but breakaway factions of the militia are continuing attacks.
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