Jean-Claude Juncker was recovering satisfactorily after a surgery for chronic digestive problems but he canceled a planned visit next week to Kazakhstan.
Juncker, who has been premier since 1995, is the longest serving EU leader and also chairs regularly monthly talks between the finance ministers of the 13 nations that use the euro.
He is known as an informal "Mr. Euro" in the absence of an official face for the currency zone and was a moving force behind the launch of the common currency in 2002.
His illness had forced him to skip a May meeting of EU finance ministers. The government said it had suddenly become worse in recent days.
Juncker is a strong advocate of EU integration and has a reputation as a canny deal maker among larger EU nations.
His official biography says his pro-European conviction was fueled by his family's experiences of World War II when his steel worker father was forcibly recruited by the occupying German army and sent to the Russian front.
Juncker also serves as a governor of the International Monetary Fund and the European Bank for Reconstruction and Development.
The United States has imposed new sanctions against the Nord Stream 2 gas pipeline project, which still remains under construction